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Real-time immune monitoring of immunocompromised patients via lens-free shadow image analysis of natural killer cells

2025-09-30

Highlights

  • Cellytics NK with Lens-Free Shadow Imaging enables rapid, accurate, cost-effective real-time assessment of NK cell activity.
  • Novel image-derived biomarkers (PPD, WSM-SD, CSP) and an Innate Immunity Index (I³) distinguish healthy from immunocompromised patients.
  • CSP and I³ show superior prognostic power, with CSP reaching diagnostic accuracy marked by an AUC above 0.95.
  • CSP and I³ outperform conventional hematological markers, including CD107a expression and interferon-γ release, in immune function assessment.
  • Successful commercialization of Cellytics NK highlights its clinical utility and transformative impact in real-world immune monitoring.

News Link : https://www.sciencedirect.com/science/article/abs/pii/S0925400525014224